Basic Information
VIS ID
TVIS44011857
Fusion event
HTLV-1-ACOXL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
111619805/110862228 (Hg38)
End
111619805/110862228 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
ACOXL
Nearest miRNA
hsa-mir-1285-2/Upstream/577285; hsa-mir-10b/Downstream/458785;
Nearest TSS
ENST00000437798/Upstream/56909; ENST00000496981/Downstream/101396;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/128921, chr2-CpG: 536/Downstream/255401
Upstream sequence
ACACCTGCTCACTGGGCCACTTCGTCCCTCCCAGTCCCCACAGCCAAGCCTCAGACAACCTGAAGGTCTCAGCCACATGCGACATTGGGAAAGCTGGTGC
Downstream sequence
TTCCCTGGAAGCTTGGCACCCTGGAACACTAGAGTTTAATTTGATTAGGATTTCACCTGATTTCTGGAGATTACAGGGCCAGAGTTATCAAGAGGGAGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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