Basic Information
VIS ID
TVIS44011861
Fusion event
HTLV-1-PRPF40A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
153541184/152684670 (Hg38)
End
153541184/152684670 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PRPF40A
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-34a-5p ; hsa-mir-32-5p ; hsa-mir-455-3p ; hsa-mir-5011-5p ; hsa-mir-4776-3p ; hsa-mir-5006-5p ; hsa-mir-3972 ; hsa-mir-1202 ; hsa-mir-190a-3p ; hsa-mir-5689 ; hsa-mir-1-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-5700
Nearest miRNA
hsa-mir-128-1/Upstream/1316259; hsa-mir-10b/Downstream/6502165;
Nearest TSS
ENST00000437798/Upstream/20815; ENST00000425034/Downstream/8441;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/348210, chr2-CpG: 169/Downstream/32559
Upstream sequence
TGCAAAGAAAACTGGGCATAAGGAAAAAAGCATACACATGTAACTATCACAAGTAATAAGCTCTTCAGAGTCAGAAAAAGCTAGTCAACAAGACACAACA
Downstream sequence
GTTTTAAAGAAATTCAATATACTCAAACTCAACCTTCTGTGTGTCATGGAGACAAACACATATACACACACATTTGTACAATGTATAAACTGAATTTATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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