Basic Information
VIS ID
TVIS44011864
Fusion event
HTLV-1-DEFB119 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
29970113/31382310 (Hg38)
End
29970113/31382310 (Hg38)
Orient
+
Location type
Intronic
Target gene
DEFB119
Nearest miRNA
hsa-mir-103a-2/Upstream/5174032; hsa-mir-1-1/Downstream/224876;
Nearest TSS
ENST00000382410/Upstream/13692; ENST00000376309/Downstream/8173;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/459762, chr20-CpG: 20/Downstream/92936
Upstream sequence
acttcctgtgaatctacaattatttcaaaataaaaagtAAAAATATCAATAAATAACCTAAGGGGCtatagagagattaaaaaaacaaaatctaaaaaac
Downstream sequence
aagaatccctaggtgaccaatcccagttcccattttacttgctgtgtatcctggggcaagtttctgcacctccctgttctaccctttttctcatatgtat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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