Basic Information
VIS ID
TVIS44011869
Fusion event
HTLV-1-LOC105369292 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
16640031/15267712 (Hg38)
End
16640031/15267712 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
LOC105369292
Nearest miRNA
hsa-mir-10396a/Upstream/1543438; hsa-let-7c/Downstream/1271377;
Nearest TSS
ENST00000624081/Upstream/200642; ENST00000464435/Downstream/134593;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/202169, chr21-CpG: 123/Downstream/461822
Nearby gene
NRIP1(-202905) ;
Upstream sequence
ACAGAAGAAAGAAACTCTAGGATAAATAGTTAGATCTTTGTTTAGAGAAAGGAGATCCAAAAGTCAAAGAATTAGACATCCAGGTTGTGACTTGCTAAGC
Downstream sequence
ATACCCACTGGCTAAACAAAGCACTGGCAAGAACATTTCGACTACGCTATTGTTACTATACTAAAATCATTCTCACCTTTAAATTGGGAGAAACATGCTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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