Basic Information
VIS ID
TVIS44011872
Fusion event
HTLV-1-DONSON integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
34959075/33586769 (Hg38)
End
34959075/33586769 (Hg38)
Orient
+
Location type
Intronic
Target gene
DONSON
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-26b-5p ; hsa-mir-23b-3p ; hsa-mir-5089-3p ; hsa-mir-340-5p ; hsa-mir-20b-3p ; hsa-mir-4307 ; hsa-mir-1183 ; hsa-mir-548at-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-5195-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-8084
Nearest miRNA
hsa-let-7c/Upstream/36041; hsa-mir-3197/Downstream/2133946;
Nearest TSS
ENST00000624081/Upstream/611; ENST00000470742/Downstream/833;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/43393, chr21-CpG: 86/Downstream/1313
Upstream sequence
tgtcgcctaggctgagtgaagtggtgtgatctcggctcagtaccaacctctgccgcctaggatcaagcgattctcgtgcctcgtcctcccgagtacctgg
Downstream sequence
gactacaggcgtgccccaccacgcctggctaatttttttgtatttttagtcgagacgggggtttcgtcatattggccaggctgttcgcgaactcctgacc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate