Basic Information
VIS ID
TVIS44011886
Fusion event
HTLV-1-KLHL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
183222485/183504697 (Hg38)
End
183222485/183504697 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
KLHL6
miRNAs that regulate target gene
hsa-mir-10a-5p
Nearest miRNA
hsa-let-7g/Upstream/6989546; hsa-mir-1224/Downstream/382103;
Nearest TSS
ENST00000440867/Upstream/75919; ENST00000491676/Downstream/40088;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/12542, chr3-CpG: 154/Downstream/130749
Upstream sequence
TTCAAGGACTTAGAAAATAGGAAGCAGAAACAAAAATAGCAAAAATATTGGAAGTATAGTTGATCAAGGCACAGTATATGTTTAAATTGTTTTAAAGTGC
Downstream sequence
TAtttattttaacttttaggttcagcatgtgcagatttgttatataggtaaattgtgtgttgtgggggtttggtgtacagattatttcatcatccgtatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate