Basic Information
VIS ID
TVIS44011911
Fusion event
HTLV-1-TBCA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
77068806/77772982 (Hg38)
End
77068806/77772982 (Hg38)
Orient
-
Location type
Intronic
Target gene
TBCA
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-501-5p ; hsa-mir-186-5p ; hsa-mir-335-3p ; hsa-mir-6875-3p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-103a-2-5p ; hsa-mir-4778-3p ; hsa-mir-6787-3p ; hsa-mir-3691-3p ; hsa-mir-1250-3p ; hsa-mir-1264 ; hsa-mir-510-3p ; hsa-mir-494-3p ; hsa-mir-186-3p ; hsa-mir-4733-5p ; hsa-mir-3156-5p
Nearest miRNA
hsa-mir-10397/Upstream/4894319; hsa-mir-103a-1/Downstream/5067173;
Nearest TSS
ENST00000502646/Upstream/57665; ENST00000510030/Downstream/3279;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/126919, chr5-CpG: 86/Downstream/2839
Upstream sequence
ATGAGTATTTTCTCTAGAATATGTATTGTCAGCATATAACTACTTGAACTAAGTAATTTTATAAACTAGTAGAGATCACTGGAATGAGAAATGTCAAGGT
Downstream sequence
CATATAAGTAAATGAATGGGAAACTACCATTAGAAGTCATTTCTCATGACTTTCATTCTACAGCACTCTGCAACACACCCTGATAGTTCTGCCAAATATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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