Basic Information
VIS ID
TVIS44011915
Fusion event
HTLV-1-MAPK9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
179669445/180242445 (Hg38)
End
179669445/180242445 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
MAPK9
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-199a-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-141-3p ; hsa-mir-215-5p ; hsa-mir-7-5p ; hsa-mir-192-5p ; hsa-mir-27b-3p ; hsa-mir-92a-3p ; hsa-mir-20b-5p ; hsa-mir-106a-5p ; hsa-mir-1178-3p ; hsa-mir-4635 ; hsa-mir-6765-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10397/Upstream/227048; hsa-mir-4638/Downstream/800958;
Nearest TSS
ENST00000502646/Upstream/33292; ENST00000504573/Downstream/455;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/33001, chr5-CpG: 133/Downstream/49083
Nearest cancer related gene
MAPK9(TSG, No orient, 0)
Upstream sequence
CTGATTTGATTATTTTTATTTTGGCCAAAGGCTTCAATTAAGCCGTCTTATAGAGGATAAAGCTTCTAGACCTTTAAGCTTTCTCTCCTCAGTGCCTTCG
Downstream sequence
TACCTCAGACTTCAGGCCTAAAATGACTTTCTCTCCCAAAACACAGGTTTTTAGAATACAAACATGAAAGAGTGAAAGCACCACCTGAATTACAAAACAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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