Basic Information
VIS ID
TVIS44011938
Fusion event
HTLV-1-TG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
134012388/133000143 (Hg38)
End
134012388/133000143 (Hg38)
Orient
-
Location type
Intronic
Target gene
TG
miRNAs that regulate target gene
hsa-let-7f-5p ; hsa-mir-550b-2-5p ; hsa-mir-7855-5p ; hsa-mir-937-5p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-5702 ; hsa-mir-1827 ; hsa-mir-1247-3p ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-758-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3611 ; hsa-mir-383-3p ; hsa-mir-6844 ; hsa-mir-7161-3p ; hsa-mir-3156-5p ; hsa-mir-185-5p
Nearest miRNA
hsa-mir-1204/Upstream/2991690; hsa-mir-10400/Downstream/46338;
Nearest TSS
ENST00000518652/Upstream/27511; ENST00000518108/Downstream/17556;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/224353, chr8-CpG: 126/Downstream/296180
Upstream sequence
CCTGTTTTACAAGTGACAGCAAGGATGCCATCATGCATTCAACAATGCAGACAGTGGTGAGAGCTCAGGCTCTGGAGGTTGATGTATGGGAGGTCAAATC
Downstream sequence
CTTAACAAATGTTAGTGAGTATGGCTGTGCCAAGCAGTTTGCAGCCATTGGATGGCTCTATTCAGCCTTCAGCCTGTGCCcagagctccctgatttatca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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