Basic Information
VIS ID
TVIS44011941
Fusion event
HTLV-1-ROR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
94674326/91912044 (Hg38)
End
94674326/91912044 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROR2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-let-7f-5p ; hsa-mir-451a
Nearest miRNA
hsa-mir-101-2/Upstream/275683; hsa-let-7a-1/Downstream/380414;
Nearest TSS
ENST00000422679/Upstream/24845; ENST00000457003/Downstream/36632;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/11508, chr9-CpG: 210/Downstream/36791
Nearest cancer related gene
ROR2(TSG, No orient, 0)
Upstream sequence
aaaaaaaaaaccacaaacccaaattaaaggacattcaacaaaatttatcggaggtactcctccaaagtgtcaaggtcaggaaaacaaggcaatactgagg
Downstream sequence
aactgtcacaaactagaaacaaattagaaaaacaggtgaactaaatgcaatgtgggatcctggatcacacaaaacagacattagtgagaaaactgctaat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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