Basic Information
VIS ID
TVIS44011944
Fusion event
HTLV-1-ATRX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
76763010/77507532 (Hg38)
End
76763010/77507532 (Hg38)
Orient
-
Location type
UTR3
Target gene
ATRX
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-21-5p ; hsa-mir-342-5p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-17-5p ; hsa-mir-200c-3p ; hsa-mir-200a-3p ; hsa-mir-129-5p ; hsa-mir-6505-5p ; hsa-mir-7850-5p ; hsa-mir-320e
Nearest miRNA
hsa-let-7f-2/Upstream/502031; hsa-mir-105-1/Downstream/1393662;
Nearest TSS
ENST00000429181/Upstream/60127; ENST00000475465/Downstream/13889;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/59351, chrX-CpG: 54/Downstream/277985
Upstream sequence
GTGTTAACCTACTAAAATGCTAGAACTTGATTTTCTAAGTCCACATCCCACTGCCAGCAACAGGATGAAGCATTAGCACTGGCACCATGCAGTTAAGAGA
Downstream sequence
TGTGCTTTATATTCGTGCCAGGAGAGAGAAAATTCATGTGTGGAAGATAATCCACAACCCTGAAATTTTACCAGTAATTATTTCAGCACATATAACTGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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