Basic Information
VIS ID
TVIS44011955
Fusion event
HTLV-1-chr14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
59891445/59424727 (Hg38)
End
59891445/59424727 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA14B
Nearest miRNA
hsa-mir-208a/Upstream/4546534; hsa-mir-1185-1/Downstream/222235;
Nearest TSS
ENST00000550708/Upstream/62466; ENST00000553156/Downstream/40614;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/235115, chr14-CpG: 189/Downstream/39189
Nearby gene
GPR135(-38795) ;
Upstream sequence
TTTTTCTTTTCTGTCACCCCCCATCACTTCATATTTTAGACAACCTAGGCCGAGGGTCCCCCATGTTCATCCCTTTCCTGCTGAGACCTAGGTCTCTTTG
Downstream sequence
GAGCAGACTCCTTCCCTAGATTAATCCCATTGTCTGACTTTTCAACATCCCACAAAGGGCTGCTATGTCCTAATcaaacaaacaaacaaacaaagaaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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