Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene238581451237042205237833988237775073237775448237811828
Basic Information
VIS ID
TVIS44011963
Fusion event
HTLV-1-RYR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
237975128/237811828 (Hg38)
End
237975128/237811828 (Hg38)
Orient
-
Location type
Intronic
Target gene
RYR2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-25-3p ; hsa-mir-17-5p ; hsa-let-7c-5p
Nearest miRNA
hsa-mir-101-1/Upstream/340637; hsa-mir-3123/Downstream/3320444;
Nearest TSS
ENST00000473358/Upstream/11799; ENST00000462585/Downstream/18204;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/27680, chr1-CpG: 91/Downstream/1575127
Upstream sequence
CCACACATAGTTGACAGCAGAGCAAATCATATTGTTCATGTGAAAATCATCTGTAATTTTCAACATTTCCTGTCACGATTGCCGTTCTGAGGTGTTTCAC
Downstream sequence
ATGTGACTTTGTGGTTTCCACGTGCTAGTGACCTACTTGGAGGACACGGAGTATCAGAGCTGAAAGGACTCTGATGTTCATGGTTGTTCATCCATAAACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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