Basic Information
VIS ID
TVIS44011984
Fusion event
HTLV-1-TRIB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
12863632/12723506 (Hg38)
End
12863632/12723506 (Hg38)
Orient
+
Location type
Exonic
Target gene
TRIB2
miRNAs that regulate target gene
hsa-mir-511-5p ; hsa-mir-1297 ; hsa-mir-106b-5p ; hsa-mir-99a-5p ; hsa-let-7c-5p ; hsa-mir-6886-3p ; hsa-mir-6880-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-942-5p ; hsa-mir-6845-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4482-3p ; hsa-mir-7159-3p
Nearest miRNA
hsa-mir-3681/Upstream/524305; hsa-mir-10b/Downstream/13861;
Nearest TSS
ENST00000437798/Upstream/5268; ENST00000434509/Downstream/814167;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/4613, chr2-CpG: 248/Downstream/1908747
Nearest cancer related gene
TRIB2(OG, No orient, 0)
Upstream sequence
TTCGTCCGCACCTGCAAGAAGCTGAGAGAGGAGGAGGCAGCCAGACTGTTCTACCAGATTGCCTCGGCAGTGGCCCACTGCCATGACGGGGGGCTGGTGC
Downstream sequence
TGCGGGACCTCAAGCTGCGGAAATTCATCTTTAAGGACGAAGAGAGGTAGGTCTCATCCTGTCCAGACCTGGGTACTGTGATGGACTGCTCCTAACAACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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