Basic Information
VIS ID
TVIS44011992
Fusion event
HTLV-1-ITGA9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37568569/37527078 (Hg38)
End
37568569/37527078 (Hg38)
Orient
-
Location type
Intronic
Target gene
ITGA9
miRNAs that regulate target gene
hsa-mir-194-5p ; hsa-mir-484 ; hsa-mir-452-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-452-3p ; hsa-mir-6794-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-759 ; hsa-mir-4639-3p ; hsa-mir-5000-5p ; hsa-mir-125b-1-3p
Nearest miRNA
hsa-mir-12127/Upstream/1782519; hsa-let-7g/Downstream/442326;
Nearest TSS
ENST00000440867/Upstream/74959; ENST00000461533/Downstream/156798;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/74031, chr3-CpG: 203/Downstream/333369
Upstream sequence
TGAATTATTAAAGAGGcagaagagccttgaggttgaatgtgaactcaggggccaggtggccgggttccagccctgactctgcccttactaggtgagtttc
Downstream sequence
ctgggcaagtcccctgacctttctgtttcaggattctcctctgtTGGCCAGGACAGCAATAcagatgctccttgacttaggatggggttatttccagata
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate