Basic Information
VIS ID
TVIS44011998
Fusion event
HTLV-1-NSUN3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
93818986/94100142 (Hg38)
End
93818986/94100142 (Hg38)
Orient
+
Location type
Intronic
Target gene
NSUN3
miRNAs that regulate target gene
hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-526b-5p ; hsa-mir-223-3p ; hsa-mir-6804-5p ; hsa-mir-935 ; hsa-mir-6507-3p ; hsa-mir-4423-3p ; hsa-mir-6758-3p ; hsa-mir-6777-3p ; hsa-mir-455-3p ; hsa-mir-4639-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-324-5p ; hsa-mir-4536-3p ; hsa-mir-6767-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-153-5p
Nearest miRNA
hsa-let-7g/Upstream/6873865; hsa-mir-12124/Downstream/2259822;
Nearest TSS
ENST00000440867/Upstream/23800; ENST00000466089/Downstream/838030;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/36878, chr3-CpG: 41/Downstream/837746
Upstream sequence
GGATTGATTGCAGATCCTTATTTTCATTTACAAAGAGCAATTGGAATGCAGATAAACAAATATTGTCTGGCCCCATATTTTGAGCAGAAGATGGCACTCA
Downstream sequence
GAAGTGAGAAAAGGAGTGGAAAAGATAGTGAAGAGGTAAATAAGGGAAACTTTCTGATTGTACTATTTTCCAAAGGCTAGACTTGTATGTACATTGTCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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