Basic Information
VIS ID
TVIS44012015
Fusion event
HTLV-1-NOX3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
155772623/155451489 (Hg38)
End
155772623/155451489 (Hg38)
Orient
-
Location type
Intronic
Target gene
NOX3
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10398/Upstream/598053; hsa-mir-1202/Downstream/495308;
Nearest TSS
ENST00000381078/Upstream/70306; ENST00000637910/Downstream/4414;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/136741, chr6-CpG: 41/Downstream/945448
Upstream sequence
CAACAGCTGCTTATACTAAATTATACTCCATCCTAAAACAGCCCTGACCACACTAGTTTCAGAAAGTTATAGCTGCTTTCAGGGTATCTTTAACACGGGG
Downstream sequence
GATATTCATTATACGTTTCTAATGCATTGGTATTATTGATACACGATTACATATAAAGAAATGTACATGCCCAAAAGTTTAAGGAGAAAACTATTTCATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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