Basic Information
VIS ID
TVIS44012018
Fusion event
HTLV-1-SUMF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
56146021/56078328 (Hg38)
End
56146021/56078328 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
SUMF2
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-218-5p ; hsa-mir-665 ; hsa-mir-6773-5p ; hsa-mir-6724-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-1273e ; hsa-mir-561-5p ; hsa-mir-8085 ; hsa-mir-296-5p ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-7160-5p ; hsa-mir-6134 ; hsa-mir-7854-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-219b-3p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-7162-3p ; hsa-mir-6840-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4695-5p ; hsa-mir-302f ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-6780a-5p ; hsa-mir-450a-1-3p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6894-5p ; hsa-mir-3922-5p
Nearest miRNA
hsa-mir-1183/Upstream/11196528; hsa-mir-10399/Downstream/877457;
Nearest TSS
ENST00000635602/Upstream/1725; ENST00000566570/Downstream/9365;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/13795, chr7-CpG: 48/Downstream/27891
Upstream sequence
TGTTGGGACCATCATGTCTGAGAGAGGAGGCAGAGGGAAGCACCTCCCTTCTGCCATTTGGCCCCCAGGACCTCAGAGGGTAGGCGGGGTGGTCGGCGGG
Downstream sequence
TCCCAGCCTGGCCTGACCCGCCGGTGGGGCTGCAGGGCTCTATGACCTCCTGGGGAACGTGTGGGAGTGGACAGCATCACCGTACCAGGCTGCTGAGCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate