Basic Information
VIS ID
TVIS44012036
Fusion event
HTLV-1-ESRP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
95689962/94677734 (Hg38)
End
95689962/94677734 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
ESRP1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-377-3p
Nearest miRNA
hsa-mir-12123/Upstream/761615; hsa-mir-10400/Downstream/395177;
Nearest TSS
ENST00000518652/Upstream/12577; ENST00000523347/Downstream/27920;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/35229, chr8-CpG: 54/Downstream/41836
Nearest cancer related gene
ESRP1(TSG, No orient, 0)
Upstream sequence
CCTTTAGGTGAGAATAATGCAGAATTGATCTGCTTGTTTCTTTTAGGTCAGTTCCTTCTGGCACAGTCTATGCTTTGACCTAATATGTGGTAGTGGCCAA
Downstream sequence
GAGAGGTTTATCATAACACTTCTCATTTGATGCTGTACTGACGGGTAGGTAGCAAGAGGGAGTAGAAGCATAACTTAAAATTTAAAATATTTAGTAGCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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