Basic Information
VIS ID
TVIS44012039
Fusion event
HTLV-1-GNAI2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
50280509/50243077 (Hg38)
End
50280509/50243077 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNAI2
miRNAs that regulate target gene
hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-138-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-935 ; hsa-mir-877-3p ; hsa-mir-92b-3p ; hsa-mir-148b-3p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-218-5p ; hsa-mir-30b-5p ; hsa-mir-4328 ; hsa-mir-6516-5p ; hsa-mir-583 ; hsa-mir-3150b-3p ; hsa-mir-4784 ; hsa-mir-625-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-6787-5p ; hsa-mir-6090 ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-4749-5p ; hsa-mir-4706 ; hsa-mir-8072 ; hsa-mir-3960 ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-3937 ; hsa-mir-455-3p ; hsa-mir-222-3p ; hsa-mir-1237-5p ; hsa-mir-2467-3p ; hsa-mir-3126-5p ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-3196 ; hsa-mir-4488 ; hsa-mir-4530 ; hsa-mir-4697-5p ; hsa-mir-6772-5p ; hsa-mir-6816-5p ; hsa-mir-6873-5p ; hsa-mir-6875-5p ; hsa-mir-922 ; hsa-mir-92b-5p
Nearest miRNA
hsa-mir-12127/Upstream/15587; hsa-let-7g/Downstream/30159;
Nearest TSS
ENST00000440867/Upstream/4965; ENST00000468422/Downstream/3817;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4864, chr3-CpG: 67/Downstream/16931
Nearest cancer related gene
GNAI2(OG, No orient, 0)
Upstream sequence
AGTGGTGTCCACACCAGAGGAAAAGGAGGAAGCAGCTGGGGGAGGAGGAGCCCAAAAGAGGAAGAGGCCAGAGGGCTGCCTGGTGCTAGGGTGGGGGTGA
Downstream sequence
GAGCCCAAGGGCCCCCCAGGGCTTTGCCAACTGGAAGGGTCTAGGAGGTGAACACCTGCCCAGGCTTATCTTTGCACTCCTGTGGGCCATTCTAGTGGCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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