Basic Information
VIS ID
TVIS44012070
Fusion event
HTLV-1-DSCAS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
28706733/31126770 (Hg38)
End
28706733/31126770 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
DSCAS
Nearest miRNA
hsa-mir-1-2/Upstream/827810; hsa-mir-122/Downstream/4464967;
Nearest TSS
ENST00000575820/Upstream/24355; ENST00000582307/Downstream/4686;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/24374, chr18-CpG: 81/Downstream/370819
Upstream sequence
TTTTAGTATGGATCTCAAAGAGGTGGGAAATACGGTGAGTGTAGGACAGTAGCACATCCCTCTTGCAGGATACCTACTATGGATGGAAGATCTTTAGAAA
Downstream sequence
CTTGGATTTTAAGAGAGATTTTGAACTATGTAAATGTCATCCACCACTCAGTACCAAATATTCTATATCTTTTAGGGGAGGCAAAGCCAAGTAAGGAAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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