Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene774031357809941379212667782926997829440778284409782859547825842678259100782900217829066778275444782760517829697678297470782775047827780078283813782840857828609778286369782910447829119378307901
Basic Information
VIS ID
TVIS44012076
Fusion event
HTLV-1-WWOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
78341798/78307901 (Hg38)
End
78341798/78307901 (Hg38)
Orient
-
Location type
Intronic
Target gene
WWOX
Nearest miRNA
hsa-mir-1225/Upstream/1438882; hsa-mir-11401/Downstream/3077117;
Nearest TSS
ENST00000527434/Upstream/66683; ENST00000620008/Downstream/116970;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/207732, chr16-CpG: 44/Downstream/1281693
Nearest cancer related gene
WWOX(TSG, No orient, 0)
Upstream sequence
CCTCCTTGCTCTCCTTACTCTTCTCCTTTTACTGAAAAGATATTTACTAGATGTCTAGCATGTTAAAGACTGTACCTTAAAAAAAAATCACACTCTAATT
Downstream sequence
TAGCACAGTTTCAATTGTGGTTAAGCACCATGCCATTCACACTTCAGAACCAAGCTCAGATCCATGTGTGACACTCTGGAATGTGGCAGCTGATGGAGGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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