Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene8383584083242990835385468350031683507325835376008353933583520818835220908351075683511962835124498351349283509116835100528350814683508295835270068352715583539415
Basic Information
VIS ID
TVIS44012085
Fusion event
HTLV-1-FRMD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
86154330/83539415 (Hg38)
End
86154330/83539415 (Hg38)
Orient
-
Location type
Intronic
Target gene
FRMD3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-377-3p ; hsa-mir-8064 ; hsa-mir-7110-3p ; hsa-mir-8485 ; hsa-mir-342-3p ; hsa-mir-6873-3p ; hsa-mir-6817-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-5007-3p ; hsa-mir-1279 ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-101-2/Upstream/12729331; hsa-let-7a-1/Downstream/430333;
Nearest TSS
ENST00000422679/Upstream/869; ENST00000530832/Downstream/83634;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/553, chr9-CpG: 86/Downstream/83427
Nearby gene
FRMD3(-982) ;
Upstream sequence
tagagccactgtgtcaggtaccgtaggcccgagagtggccaggagcagctgttgagtcaggggtatggagcttgaatgtgagcactagaatgtccaGGAG
Downstream sequence
CTGGGAGAGATGGAAGTCCTCTCACCCTGTTGCTCTTGCCGGAGCAGAACAGGTCATTAGGAAGGAACATTTGTTAGAAGAGGAGGTGTTGACCAGCTGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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