Basic Information
VIS ID
TVIS44012130
Fusion event
HTLV-1-DOCK9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
99683386/99031132 (Hg38)
End
99683386/99031132 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
DOCK9
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-32-5p ; hsa-mir-16-5p ; hsa-mir-214-3p ; hsa-mir-218-5p ; hsa-mir-4477a ; hsa-mir-889-3p ; hsa-mir-1295b-3p ; hsa-mir-3142 ; hsa-mir-1245b-5p ; hsa-mir-1277-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1297/Upstream/822532; hsa-mir-1267/Downstream/324999;
Nearest TSS
ENST00000623511/Upstream/15080; ENST00000562781/Downstream/55261;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/278283, chr13-CpG: 222/Downstream/54945
Upstream sequence
TCCAAAAACTCATGTAAATTATCTCAAAAAAAAAATTAACAACATAGACTTTATAATAAATATCTTACTTTCTGTAATTGATGTTTTTTTTAAAAAAAAG
Downstream sequence
TATCCTTATCACTTTTTAAAATTAATTTCTGGTGCTTTTATAGCATAAAATTATTTTCTGCAATAGAATCGCAATTTGTAACATTGTGCCAAGGAAATGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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