Basic Information
VIS ID
TVIS44012160
Fusion event
HTLV-1-LL22NC01-81G9.3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
37363458/36967417 (Hg38)
End
37363458/36967417 (Hg38)
Orient
+
Location type
ncRNA_exonic
Fragile sites / regions
FRA22A
Target gene
LL22NC01-81G9.3
Nearest miRNA
hsa-mir-1286/Upstream/680510; hsa-let-7a-3/Downstream/876855;
Nearest TSS
ENST00000624155/Upstream/2169; ENST00000628507/Downstream/34839;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/110750, chr22-CpG: 154/Downstream/50861
Upstream sequence
gagcctctgcaacagcccaatggagaaatggaggagtttccaggcccacgtgacactgaatcacaattgtcttttaccgcttgggatgatgatgccatca
Downstream sequence
cttttctctaatttttttttttttttttgaggcagcctcactgtcacccaggctggagtgtagtggcgtgatcttggcttactgaaacctccacctcccg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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