Basic Information
VIS ID
TVIS44012166
Fusion event
HTLV-1-chr5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
178024953/178597952 (Hg38)
End
178024953/178597952 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5G
Nearest miRNA
hsa-mir-10397/Upstream/1968452; hsa-mir-1229/Downstream/1200326;
Nearest TSS
ENST00000502646/Upstream/7397; ENST00000520377/Downstream/19436;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/7283, chr5-CpG: 99/Downstream/28479
Nearby gene
CLK4(-4712) ;
Upstream sequence
TTGAGTGTCAGAGAGGATCTGGGACTAAGGTTCTAACCATGGTGCAAAAAATCCAAGTCCTTTCAATACACTAAGCTGCTACCTCAAGGAAGTAGATGAT
Downstream sequence
AAATAAGAAATGAAAGGCAGAAAGAGCTAAAACCTTTATATTACAGCTTCAACCTAGAGGCTTAATCCCAGGTACAACTTTTTAAGAAAATGATACGTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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