Basic Information
VIS ID
TVIS44012168
Fusion event
HTLV-1-KMT2C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
151860691/152163606 (Hg38)
End
151860691/152163606 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA7I
Target gene
KMT2C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-128-3p ; hsa-mir-26b-5p ; hsa-mir-940 ; hsa-mir-708-5p ; hsa-mir-106b-3p ; hsa-mir-652-3p ; hsa-mir-615-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-15b-5p ; hsa-mir-196a-5p ; hsa-mir-610 ; hsa-mir-93-3p ; hsa-mir-4663 ; hsa-mir-4632-3p ; hsa-mir-6746-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-934
Nearest miRNA
hsa-mir-10399/Upstream/729967; hsa-mir-153-2/Downstream/5410730;
Nearest TSS
ENST00000635602/Upstream/272; ENST00000564834/Downstream/14362;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/32049, chr7-CpG: 31/Downstream/203143
Nearest cancer related gene
KMT2C(TSG, No orient, 0)
Upstream sequence
TGGGCAATTGGGGGCTGAATTCTAGGAGGATTGAGGGGCAGGTGGGCAGGAGCACTGTTGGGTTGCCATCCAGGTAAACTGGGCATTCTAACAGGGCTAG
Downstream sequence
TATGGCCAGAAATAACTGTTGTGTGCTGCTGGTGCTGAAGCTGCTGTGGCACCATGGGAAAGGTGGGTTGGCTCATGGTGGGTGGAGTGGCACCTGGAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate