Basic Information
VIS ID
TVIS44012172
Fusion event
HTLV-1-AKT3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
243923292/243759990 (Hg38)
End
243923292/243759990 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1I
Target gene
AKT3
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-519d-3p ; hsa-mir-29c-3p ; hsa-mir-124-3p ; hsa-mir-146b-5p ; hsa-mir-2054 ; hsa-mir-297 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-6134 ; hsa-mir-7854-3p ; hsa-mir-4725-5p ; hsa-mir-545-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4781-3p ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-646 ; hsa-mir-6758-5p ; hsa-mir-595 ; hsa-mir-503-5p ; hsa-mir-497-5p ; hsa-mir-195-5p ; hsa-mir-6838-5p ; hsa-mir-424-5p ; hsa-mir-15b-5p ; hsa-mir-374a-3p ; hsa-mir-361-5p ; hsa-mir-569 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-873-5p ; hsa-mir-7-5p ; hsa-mir-552-5p ; hsa-mir-5582-5p ; hsa-mir-708-3p ; hsa-mir-548an ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-29b-1-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/413735; hsa-mir-3124/Downstream/3441977;
Nearest TSS
ENST00000473358/Upstream/64274; ENST00000440494/Downstream/54692;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/270529, chr1-CpG: 166/Downstream/89420
Upstream sequence
TTAGGACTCTGATAAGTCAATTGCCACATTAAGCTGAAATCACAAATGGCTGATCGTTAATGTCAATGGGGAACCAAAAAATAAACTAAATCTTGCACAG
Downstream sequence
ATCTGCACCCTAGATTCATGTCACCTGAGTGGACCAGGAAACTTTAGGCTTTAAACTTGGGTTAGGCTACTCCTAGATTGCTATCCAAGGCATCCAGCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate