Basic Information
VIS ID
TVIS44012175
Fusion event
HTLV-1-RAG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p12
Reference genome
GRCh37/hg19
Start
36535791/36514241 (Hg38)
End
36535791/36514241 (Hg38)
Orient
+
Location type
Intronic
Target gene
RAG1
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4795-5p ; hsa-mir-1283 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548g-3p ; hsa-mir-548av-3p ; hsa-mir-5696 ; hsa-mir-4729 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-6771-3p ; hsa-mir-4694-3p
Nearest miRNA
hsa-mir-1343/Upstream/504037; hsa-let-7a-2/Downstream/7045415;
Nearest TSS
ENST00000527297/Upstream/3532; ENST00000299440/Downstream/1223;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3774, chr11-CpG: 49/Downstream/6797648
Nearby gene
TRAF6(-3928) ;
Upstream sequence
tgaggctttctgccaaagccttgtgagtgagtcatcctggaagtggatcttccagccccagtcaagccatcagatgacatcttgactgcaatctcacaag
Downstream sequence
agaccctaagctggaacctacaaaaactgtgatataataaatgttgtcttaagctctaaagtttgggtaatttggtacacagcaatagataattaataGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate