VISDB - VIS Detail

Basic Information

VIS ID

TVIS44012177

Fusion event

HTLV-1-BCAT1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr12

Cytoband

p12.1

Reference genome

GRCh37/hg19

Start

24990748/24837814 (Hg38)

End

24990748/24837814 (Hg38)

Orient

Location type

Intronic

Target gene

BCAT1

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-32-5p ; hsa-mir-21-5p ; hsa-mir-769-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-3692-3p ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-3190-3p ; hsa-mir-593-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-7113-5p ; hsa-mir-140-3p ; hsa-mir-4328 ; hsa-mir-211-3p ; hsa-mir-4733-3p ; hsa-mir-6753-5p ; hsa-mir-106a-3p ; hsa-mir-137 ; hsa-mir-3152-3p ; hsa-mir-5589-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-25-3p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-548j-3p ; hsa-mir-548x-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4778-3p ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-146a-3p

Nearest miRNA

hsa-mir-1244-3/Upstream/625319; hsa-let-7i/Downstream/1036206;

Nearest TSS

ENST00000382841/Upstream/7393; ENST00000546353/Downstream/43584;

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/274454, chr12-CpG: 70/Downstream/64851

Upstream sequence

ccgcacccagccTAAGAGTCTATCTTTAGTGATTTTCAAACCTGGTGGAGCATCAGCAACAAGTATGGAGATGCTGCCTTTGCTCTCTGAGATTCAAATG

Downstream sequence

TAATGGGCTTATCAGAGTGAGCTCAAGCACGTGTACGGTTAAAAAAGAAGACATTCAAGAAACAAAACTCCAAAGCTGAGCTACTGCTCTACTGTGAGAT

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.