Basic Information
VIS ID
TVIS44012182
Fusion event
HTLV-1-ABCC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
95826912/95174658 (Hg38)
End
95826912/95174658 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA13D
Target gene
ABCC4
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-324-5p ; hsa-mir-23b-3p ; hsa-mir-3924 ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-8064 ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-1277-5p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p
Nearest miRNA
hsa-mir-1297/Upstream/2684438; hsa-mir-1267/Downstream/1252571;
Nearest TSS
ENST00000623511/Upstream/25698; ENST00000376855/Downstream/126644;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/171507, chr13-CpG: 120/Downstream/126348
Upstream sequence
TCCTTAAAGGTGCAAGAGGACTTTATAAATACCTCCTGTGTTCAAATGAAAATCTGAGGGAGCTTGTGCGATACGCACACTGATACTCAGCAATGAAAAT
Downstream sequence
ACCTTCCTCCTTCCCCGCGGCGACTCTAAACAGCGTCCCACCGGGAATTGTTGTTTGAGTGATAAAGAACTGGTGGGGCCTCGCGCAAGACTCAAGCAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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