Basic Information
VIS ID
TVIS44012184
Fusion event
HTLV-1-NUMB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
73790426/73323718 (Hg38)
End
73790426/73323718 (Hg38)
Orient
-
Location type
Intronic
Target gene
NUMB
miRNAs that regulate target gene
hsa-mir-31-5p ; hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-29c-3p ; hsa-mir-103a-3p ; hsa-mir-146a-5p ; hsa-mir-1277-5p ; hsa-mir-4684-5p ; hsa-mir-107 ; hsa-mir-4738-3p ; hsa-mir-1184 ; hsa-mir-6074 ; hsa-mir-4496 ; hsa-mir-3163 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-509-5p ; hsa-mir-4418 ; hsa-mir-509-3-5p ; hsa-mir-548av-3p ; hsa-let-7c-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-208a/Upstream/806820; hsa-mir-1185-1/Downstream/435029;
Nearest TSS
ENST00000550708/Upstream/24343; ENST00000304061/Downstream/32051;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/77515, chr14-CpG: 55/Downstream/134163
Nearest cancer related gene
NUMB(TSG, No orient, 0)
Upstream sequence
AGACAAAGTATATATACATATCTTTTAAAAAGCACAAACAAAAATGACAGTTTTTCAAAGACTGAAGAAATCACACATTCCTTTTATGGGGAGCATATAA
Downstream sequence
GAGCATGGCAGATCACCAAAACAAATTTTATGAAGGTATTACATCTGAGCTTGAAAAGATACATAAAATTTGAAGAGGCAAAAATTGAAAGGTTGAAAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate