Basic Information
VIS ID
TVIS44012187
Fusion event
HTLV-1-ARHGAP28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
6825804/6825805 (Hg38)
End
6825804/6825805 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP28
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-196a-5p ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-3976/Upstream/451380; hsa-mir-1-2/Downstream/3933779;
Nearest TSS
ENST00000575820/Upstream/37311; ENST00000581099/Downstream/8670;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/95767, chr18-CpG: 27/Downstream/94787
Nearby gene
ARHGAP28(+8628) ;
Upstream sequence
atttggttttcccttcctgtgttaatttgtttaggattatggccaccagctccattctcattgctgcaaaggacatgatttcactcttttttatggctgc
Downstream sequence
atagtatcccatcttgtatatgtatcacattttctttatccagtcctccaatcatgggtagctaggttgattccatatctttgcaattgtgaatagcttg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate