Basic Information
VIS ID
TVIS44012192
Fusion event
HTLV-1-PLCB4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
9345916/9365269 (Hg38)
End
9345916/9365269 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20B
Target gene
PLCB4
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-412-3p ; hsa-mir-371a-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1993577; hsa-mir-1-1/Downstream/1284367;
Nearest TSS
ENST00000382410/Upstream/57469; ENST00000464199/Downstream/5665;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/295898, chr20-CpG: 32/Downstream/141195
Upstream sequence
tagataagaaacaaaaatattttagtataagtatatcctatggaatgtttggagcatacttacagtaaaagaaaattacctgttgtttttctgaaattca
Downstream sequence
agtttaactgagagctctatatatttatgtgctaaatctgacaaccctaAATTCATCTTATAGCACATAATTGTCTGATTTTCAGAACCAATGTTCTTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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