Basic Information
VIS ID
TVIS44012200
Fusion event
HTLV-1-UNC5C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
96287988/95366837 (Hg38)
End
96287988/95366837 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
UNC5C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4477b ; hsa-mir-488-3p ; hsa-mir-4496 ; hsa-mir-323a-3p ; hsa-mir-651-3p ; hsa-mir-6762-3p ; hsa-mir-93-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-500a-5p ; hsa-mir-222-5p ; hsa-mir-6806-5p ; hsa-mir-5088-3p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936
Nearest miRNA
hsa-mir-12113/Upstream/8066254; hsa-mir-1243/Downstream/3630550;
Nearest TSS
ENST00000502981/Upstream/31205; ENST00000605849/Downstream/182135;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/608179, chr4-CpG: 20/Downstream/181468
Nearest cancer related gene
UNC5C(TSG, No orient, 0)
Upstream sequence
TTGGTTTTGTTTCTTTTTTAATTGTTAAGCGAATTTTTGTCACATTAAAACAGCAGAGCTAAACATTGAGGCTGTTATTTCAAAAGAAAAATAACTTTTC
Downstream sequence
TTTGTGAGGCAATTTATACCAAAACTTTTCTGTTTTTGCCCAAGTATAATTTGCAATGCCATCAGGCTTGCTGGCAGCAGAGGGATATTGTAAGCCATCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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