Basic Information
VIS ID
TVIS44012203
Fusion event
HTLV-1-LOC105377730 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
172208476/172781473 (Hg38)
End
172208476/172781473 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
LOC105377730
Nearest miRNA
hsa-mir-10397/Upstream/119210; hsa-mir-10523/Downstream/133610;
Nearest TSS
ENST00000502646/Upstream/10278; ENST00000518260/Downstream/35148;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/8870, chr5-CpG: 51/Downstream/52669
Nearby gene
DUSP1(-10273) ;
Upstream sequence
atctgcctgcctcagcctcccaaagtgctgggattacaggcgtgagccaccacacctggcctagatttccactgttaatcataataagagacaagaaaat
Downstream sequence
tacttaagagactgtttctcatccatcatcagattagccaaaatccaaaaacttgacagcaccctctgggacaagggaaacctgactatggactggatat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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