Basic Information
VIS ID
TVIS44012206
Fusion event
HTLV-1-MANEA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
96030773/95582897 (Hg38)
End
96030773/95582897 (Hg38)
Orient
-
Location type
Intronic
Target gene
MANEA
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-1468-3p ; hsa-mir-545-3p ; hsa-mir-205-3p ; hsa-mir-4461 ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-548p ; hsa-mir-6859-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-3120-3p
Nearest miRNA
hsa-mir-10398/Upstream/4061160; hsa-mir-1202/Downstream/2441634;
Nearest TSS
ENST00000381078/Upstream/5354; ENST00000474553/Downstream/5325;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/4731, chr6-CpG: 26/Downstream/433096
Upstream sequence
atgtatgtggtgtacatatatgtatgaatatgtgtgtatttatgtatatgtgtgtatCCTCTCTTTAATATAttgtctcatggttcctcgtgattagatc
Downstream sequence
tggattaatttttaacaagagtaccacagcagtgattctgtgtttttctcagtacgggttcgctgaagactaatggccatacttatttatccaaattaac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate