VISDB - VIS Detail

Basic Information

VIS ID

TVIS44012209

Fusion event

HTLV-1-CREB3L2 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr7

Cytoband

q33

Reference genome

GRCh37/hg19

Start

137620031/137935285 (Hg38)

End

137620031/137935285 (Hg38)

Orient

Location type

Intronic

Target gene

CREB3L2

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-19b-3p ; hsa-mir-92a-3p ; hsa-mir-16-5p ; hsa-mir-19a-3p ; hsa-mir-4524a-3p ; hsa-mir-374a-5p ; hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-7109-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-6770-5p ; hsa-mir-6760-5p ; hsa-mir-6856-5p ; hsa-mir-6873-5p ; hsa-mir-6758-5p ; hsa-mir-4428 ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-450b-5p ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-4696 ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-3127-5p ; hsa-mir-2861 ; hsa-mir-3934-3p ; hsa-mir-767-3p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-3918 ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-7705 ; hsa-mir-4512 ; hsa-mir-6854-5p ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-1-3p ; hsa-mir-206 ; hsa-mir-613

Nearest miRNA

hsa-mir-10525/Upstream/1031991; hsa-mir-10399/Downstream/188473;

Nearest TSS

ENST00000635602/Upstream/1395; ENST00000418554/Downstream/18063;

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/87649, chr7-CpG: 62/Downstream/66260

Upstream sequence

ttccggccttgtgtcatgagaattaaactaaataatgcacgtaatacacctaacacttcactgcatagcaATCTTTTAAAAAGCTCTTTTAAAAAACTAA

Downstream sequence

CATAATTAAAACAATAAAATGTTGGCATTTTCTACTTGCACACCAGCTTCTCGCATTGTTCTTCCTAGAATATGCTTTCATTTTCATCTTTACCAAACAG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.