Basic Information
VIS ID
TVIS44012220
Fusion event
HTLV-1-UQCRB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
97247326/96235098 (Hg38)
End
97247326/96235098 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
UQCRB
miRNAs that regulate target gene
hsa-mir-423-3p ; hsa-mir-1273e ; hsa-mir-4473 ; hsa-mir-3678-3p ; hsa-mir-4671-3p ; hsa-mir-155-5p ; hsa-mir-569 ; hsa-mir-2467-3p ; hsa-mir-4424 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-411-5p ; hsa-mir-5579-3p ; hsa-mir-16-1-3p ; hsa-mir-7705 ; hsa-mir-1244 ; hsa-mir-590-5p ; hsa-mir-21-5p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-5096 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-1200 ; hsa-mir-378a-5p ; hsa-mir-197-3p ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-3663-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-4641 ; hsa-mir-627-3p ; hsa-mir-3124-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p
Nearest miRNA
hsa-mir-12123/Upstream/1162102; hsa-mir-10400/Downstream/2158547;
Nearest TSS
ENST00000518652/Upstream/1183; ENST00000520575/Downstream/329;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/73446, chr8-CpG: 111/Downstream/26289
Upstream sequence
CGCGAGGGGTGCAATGATATTTCCAATTCTACTTCCTTGGGtcactttgcctcagttatcttatcagcgtaaaagggaaattaatatctccctcgtcgca
Downstream sequence
atggcaagaaaatttatagggccaatgcacacgatagagcacttgggtcatagaaagcactGAGCTCATTCGGGTTGAAAGTCATCCACTAGTTATCCTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate