Basic Information
VIS ID
TVIS44012223
Fusion event
HTLV-1-HEATR5A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
31805626/31336420 (Hg38)
End
31805626/31336420 (Hg38)
Orient
-
Location type
Intronic
Target gene
HEATR5A
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-5587-5p ; hsa-mir-197-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-6801-5p ; hsa-mir-193b-5p ; hsa-mir-6131 ; hsa-mir-3663-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4716-5p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-4781-3p ; hsa-mir-483-5p ; hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-4531 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-432-5p ; hsa-mir-4778-3p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-141-5p ; hsa-mir-122-5p ; hsa-mir-1289 ; hsa-mir-1304-3p ; hsa-mir-143-5p ; hsa-mir-3135b ; hsa-mir-3198 ; hsa-mir-3652 ; hsa-mir-3664-5p ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4430 ; hsa-mir-4534 ; hsa-mir-4639-3p ; hsa-mir-504-3p ; hsa-mir-5693 ; hsa-mir-5698 ; hsa-mir-6499-3p ; hsa-mir-6514-5p ; hsa-mir-6794-3p ; hsa-mir-8082 ; hsa-mir-891a-3p
Nearest miRNA
hsa-mir-208a/Upstream/321678; hsa-mir-1185-1/Downstream/5615889;
Nearest TSS
ENST00000550708/Upstream/38700; ENST00000550431/Downstream/1174;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/128180, chr14-CpG: 86/Downstream/83542
Upstream sequence
tggcctcaggccatcctcccatcttggcctcccaaagtgctgagattacaagcatgagctagtgtgtctggcccccagggctgtttttgaactcctgacc
Downstream sequence
taaaacagtcctctcgccttagcctcacaaagtgcttaagattacaggtgtgagccaccatacctggccTATTATTACTATTTTTGTAGGCTAATAGTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate