Basic Information
VIS ID
TVIS44012229
Fusion event
HTLV-1-CCDC146 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
76788988/77159671 (Hg38)
End
76788988/77159671 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
CCDC146
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10525/Upstream/1244402; hsa-mir-10399/Downstream/15044344;
Nearest TSS
ENST00000635602/Upstream/37054; ENST00000461882/Downstream/40155;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/37594, chr7-CpG: 111/Downstream/255852
Upstream sequence
gtaaatagtgatgaaatgaacgtgggagtgccaatatcgcttcgagatcctgatttcgattcatttggatatataaccagaagaattgctggataataag
Downstream sequence
gaaggtttattttttactttttgaggaaacttcatactgttttctataatggtttaccaacttaccttcccactaacagtgtacaagggttcctttttct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate