Basic Information
VIS ID
TVIS44012236
Fusion event
HTLV-1-DPYD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
98384502/97918946 (Hg38)
End
98384502/97918946 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1M
Target gene
DPYD
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-302b-3p ; hsa-mir-494-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3375167; hsa-mir-11399/Downstream/126296;
Nearest TSS
ENST00000473358/Upstream/121981; ENST00000418344/Downstream/2051;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1196683, chr1-CpG: 47/Downstream/1687
Upstream sequence
TTAAAATATTACTTGCTTATCCATGTATTTGAAGCTAAAACAATGATCACAATCAGATCTCTAGACAATGGTTGTAATGAATTTGTTCAAGAAAAGCATT
Downstream sequence
CAAATTTGATGGAAAACTGAGCCTTTATAATTCATTCTAATTCTTCAACACAAAAATGAACTTTGGTAAATCAATAGGATCAACTGAGGCATTTATGCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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