Basic Information
VIS ID
TVIS44012238
Fusion event
HTLV-1-SWT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
185229218/185260086 (Hg38)
End
185229218/185260086 (Hg38)
Orient
+
Location type
Intronic
Target gene
SWT1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-101-1/Upstream/4821696; hsa-mir-1182/Downstream/7456242;
Nearest TSS
ENST00000473358/Upstream/102604; ENST00000609881/Downstream/40832;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/102513, chr1-CpG: 114/Downstream/56111
Upstream sequence
ATCTAATCTGTTATATAGCAAGAGTCATGGGTGAGTACTTTAGAAATGCCTTGGAACTCACAAAGCATACTTGTTATTTTTAAGCTTAGGATGGGAAAGG
Downstream sequence
AAAACAATGGTTATTTATTTTAGAGGATGAGTGCACATGATGGCTTAGGTGGTACCAAATAGATAAGGGAAATCATCCTTAAGCCCAAGGGGCAACTGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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