Basic Information
VIS ID
TVIS44012249
Fusion event
HTLV-1-PRDM11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
45184890/45163339 (Hg38)
End
45184890/45163339 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRDM11
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1184 ; hsa-mir-1205 ; hsa-mir-17-3p ; hsa-mir-3158-5p ; hsa-mir-544a
Nearest miRNA
hsa-mir-129-2/Upstream/1581856; hsa-let-7a-2/Downstream/528365;
Nearest TSS
ENST00000527297/Upstream/15996; ENST00000534751/Downstream/18538;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/15789, chr11-CpG: 98/Downstream/16893
Nearest cancer related gene
PRDM11(TSG, No orient, 0)
Upstream sequence
CATGCGTGCTGACCCTTCAAGTTCCTATGGATCACTCCCAGCCTACTGGGTGATTTAAATGCACACATTTTTCATTTCGATTTCATTTCTTTTCAATAAC
Downstream sequence
GAGCCCATCTTTAACCAAGGTCTTGGACAAGGTCCCACAGGCATGGAGCGGGATTCCAGTGTGCCTCACCTACTGCCTTCTGAGGAGCCCTCCTCTGCTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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