Basic Information
VIS ID
TVIS44012250
Fusion event
HTLV-1-GUCY1A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
106880696/107009970 (Hg38)
End
106880696/107009970 (Hg38)
Orient
+
Location type
Intronic
Target gene
GUCY1A2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-3619-3p ; hsa-mir-3917 ; hsa-mir-7705 ; hsa-mir-6512-5p ; hsa-mir-625-3p ; hsa-mir-145-3p ; hsa-mir-1288-5p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-330-3p
Nearest miRNA
hsa-mir-10392/Upstream/3159990; hsa-let-7a-2/Downstream/4337787;
Nearest TSS
ENST00000527297/Upstream/877854; ENST00000529675/Downstream/8181;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/931881, chr11-CpG: 137/Downstream/7627
Upstream sequence
cctctagacataccttcagcatgctgagcaattacctggagttttgttcaaaatgtagtttgggcccctccctggaactatccaaccagatcctctgagg
Downstream sequence
atgagacccaggaatctgcattctaacaattttcctcaggtatgtcttgtgttcaatgaagcttgagagctactAGATTAAATGAAGAACTGTTTAATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate