Basic Information
VIS ID
TVIS44012251
Fusion event
HTLV-1-chr12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12058950/11906016 (Hg38)
End
12058950/11906016 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1244-3/Upstream/2666465; hsa-let-7i/Downstream/205936;
Nearest TSS
ENST00000382841/Upstream/20079; ENST00000484949/Downstream/143828;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/256397, chr12-CpG: 102/Downstream/360729
Nearby gene
ETV6(+10625) ;
Nearest cancer related gene
ETV6(TSG, +10625) ;
Upstream sequence
ATGAAATGTGGTGTACCAAAGAAAGGAAACATATCTGAAAGAGATATGGAAGAGTATGGAAAATACACTTTCCCAAAGTTATAATTTCACCTTAGGCCAG
Downstream sequence
TCCCATCTCTCTACTATATTGACTTCTTAAACCTTTCCAACCTTTTCATGTCCTTTTCTCAGGAATCCTGTCACCCACAAGAATGTAGCCCACTTTGTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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