Basic Information
VIS ID
TVIS44012257
Fusion event
HTLV-1-DNAJC15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
43651590/43077454 (Hg38)
End
43651590/43077454 (Hg38)
Orient
+
Location type
Intronic
Target gene
DNAJC15
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-8068 ; hsa-mir-5087 ; hsa-mir-657 ; hsa-mir-3665 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-5580-3p ; hsa-mir-5589-3p ; hsa-mir-574-5p ; hsa-mir-135b-3p ; hsa-mir-4278 ; hsa-mir-6867-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-625-5p ; hsa-mir-6732-5p ; hsa-mir-6805-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p
Nearest miRNA
hsa-mir-2276/Upstream/1509059; hsa-mir-1267/Downstream/1118675;
Nearest TSS
ENST00000623511/Upstream/54251; ENST00000425609/Downstream/81177;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/53734, chr13-CpG: 159/Downstream/708444
Upstream sequence
ataaacaactccagaaagaaagggaaggacaagttaggcttcagtgcattcctacaaaagcctcagccaatctcacaataacctctaagcaaggatggct
Downstream sequence
cattgtagttatcccaagttggggcaaggggtcataggattaaatgacattacccaggaagtgagcatatatataagaagtccaaggactgaaccctaga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate