Basic Information
VIS ID
TVIS44012266
Fusion event
HTLV-1-FUT8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
65957644/65490926 (Hg38)
End
65957644/65490926 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
FUT8
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-122-5p ; hsa-mir-26a-5p ; hsa-mir-455-3p
Nearest miRNA
hsa-mir-208a/Upstream/19740; hsa-mir-1185-1/Downstream/1950929;
Nearest TSS
ENST00000550708/Upstream/2608; ENST00000554765/Downstream/145590;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/77274, chr14-CpG: 40/Downstream/522689
Upstream sequence
TCCGAGTTAATTACCATTTCTTTTGCAGATGGCAGTTATGCTGAATATTGATCATAAGATACAATAACATATCTTGGATTCTCACCACAGTTTTACAGTG
Downstream sequence
TTACCTACTCAGAATCTGGTTCAAAATTGTAGTGACTTGTTGAATTGCACATAGGGAAATTTGAAGAGCCTTCTGCTAAAGCCAACAATTTAACACTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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