Basic Information
VIS ID
TVIS44012276
Fusion event
HTLV-1-ARHGAP27 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
43509598/45432232 (Hg38)
End
43509598/45432232 (Hg38)
Orient
-
Location type
UTR5
Target gene
ARHGAP27
miRNAs that regulate target gene
hsa-mir-198 ; hsa-mir-4726-3p ; hsa-mir-1324 ; hsa-mir-589-3p ; hsa-mir-500b-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-1199-3p ; hsa-mir-4632-3p ; hsa-mir-1908-3p
Nearest miRNA
hsa-mir-1180/Upstream/317799; hsa-mir-10226/Downstream/43131;
Nearest TSS
ENST00000595228/Upstream/1935; ENST00000433601/Downstream/117;
Nearest CpG islands
chr17-CpG: 299/Target, None/Upstream, None/Downstream
Upstream sequence
TCATTTGCACCCTGAATCACCCACTGCGAGCCCTTCCAACCGGATTGCAAATCCGCCCGCTCCGGGCCCACCTCTTCCCTCACCAGGGCCTTTCCCGGAG
Downstream sequence
CAGCCCGGCCGGGCCTGGAAAAACTCCGAGCGGGATTCCCAGCGCAGGGACGCCCACCGGAGCTCGATGTCTCGGGCTGGATAAGAAGGGGACCGGACCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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