Basic Information
VIS ID
TVIS44012283
Fusion event
HTLV-1-ESCO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
19166746/21586785 (Hg38)
End
19166746/21586785 (Hg38)
Orient
-
Location type
Intronic
Target gene
ESCO1
miRNAs that regulate target gene
hsa-mir-143-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6499-3p ; hsa-mir-6787-3p ; hsa-mir-342-3p ; hsa-mir-5693 ; hsa-mir-383-3p ; hsa-mir-3065-3p ; hsa-mir-1228-3p ; hsa-mir-216b-5p ; hsa-mir-216a-5p ; hsa-mir-1294 ; hsa-mir-3190-5p ; hsa-mir-3671 ; hsa-mir-3926 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-548s ; hsa-mir-5579-3p ; hsa-mir-607 ; hsa-mir-6849-3p ; hsa-mir-4652-3p ; hsa-mir-4778-5p
Nearest miRNA
hsa-mir-3156-2/Upstream/6756543; hsa-mir-1-2/Downstream/96733;
Nearest TSS
ENST00000575820/Upstream/25804; ENST00000579618/Downstream/13919;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/343397, chr18-CpG: 107/Downstream/13303
Upstream sequence
caaagagagagagttttactgcttcctttccaatctggacgccttttatttctttcccttttgccagtctaccttggctagaacctccagtggaaacctc
Downstream sequence
ctcctttccactgttgaaagaagtggtaagagcaggtatcttcatcttattcctaagtttagggggaaagctctcagtcttgcatactgttaggtatgat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate